Skinceuticals A.G.E. Interrupter review

Can you interrupt A.G.E.?

A.G.E. stands for advanced glycation end-products, abnormal structures that damage collagen and make your skin sag and age faster.

What causes them? Sugar. The more you eat, the more A.G.E.s your skin produces. Bummer!

I need my sugar fix every now and then, so I’m looking for other ways to undo, or at least stop, the damage A.G.E.s cause to my skin.

Enter Skinceuticals A.G.E. Interrupter. It features 30% proxylane™ to fight the wrinkles and sagging caused by the glycation process. Does it work?

What’s In Skinceuticals A.G.E. Interrupter?


Developed by L’Oreal (the owners of Skinceuticals), Proxylane is a sugarprotein hybrid derived from xylose, a natural sugar found in beechwood.

According to L’Oreal, Pro-Xylane boosts the production of glycosaminoglycans (GAGs), a component of your natural skin’s barrier. The more GAGs your skin has, the more hydrated and firmer it is.

Related: I Went On The Low Glycemic Diet And It Transformed My Skin


The base of this moisturiser is made up of silicones. It’s not as bad as you think. Silicones do a lot of good things in skincare:

  • Enhance texture: They allow the cream to glide on smoothly, without tugging or pulling.
  • Fill in fine lines and wrinkles: It’s a trick to make them look temporarily smaller.
  • Softens skin: It makes it feel silky soft to the touch.

They don’t even cause pimples: silicones have a particular molecular structure made up of larger molecules with wider spaces between each molecule. They create a barrier that keeps moisture in but still allows skin to perspire.

But if you use anything comedogenic before this cream, then yes, silicones can trap them underneath their protective barrier and cause breakouts.

Bottom line: don’t use comedogenic ingredients in your skincare and you’ll be fine.

Related: Are Silicones In Skincare Bad?

Struggling to put together a skincare routine that minimises wrinkles, prevents premature aging, and gives your complexion a youthful glow? Download your FREE “Best Anti-Aging Skincare Routine” to get started (it features product recommendations + right application order):


Mousse-like, whipped texture. In the jar, it looks thicker than it is on the skin. It sinks in quickly, too.


White florals. I personally don’t like the smell of white florals, but I know many people who adore it. Just a matter of personal preference.

How To Use It

In the AM, in between serum and sunscreen. At night, it’s the last step of your skincare routine.

Performance & Personal Opinion

Skinceuticals A.G.E. Interrupter isn’t the most moisturising cream I’ve tried. If you’ve got dry skin, this ain’t gonna cut it. You can pile it on and still your skin will demand more moisture than it can give it.

Oily and combination skin types will like it a lot better. It adds just that little extra touch of hydration your skin needs to stay soft and supple during the day/night.

Still, it’s more of a maintenance cream than anything else. You won’t see much improvement in the texture and brightness of your skin. It just keeps the status quo, so your skin doesn’t get worse.

I’m also not convinced that this alone can fight A.G.E.s. A diet mostly free of sugar (come on, you need a cheat day every now and then) will help more with this than any cream you can buy.

At least, it’s not comedogenic. I’ve been using it for weeks and not a single pimple has reared its ugly head.

skinceuticals age interrupter

Who Is This For?

It’s best suitable for combination skin.

Who Is This NOT For?

  • Dry skin – not moisturising enough for you.
  • Sensitive skin – fragrance may irritate your skin.
  • If you want to fight A.G.E.s, your best bet is still to minimise sugar consumption.


A sleek jar with a black cap. I’m not a big fan of jars because they’re not hygienic. Thankfully, it comes with a spatula – problem solved.

Does Skinceuticals A.G.E. Interrupter Live Up To Its Claims?

High-concentration anti-wrinkle cream formulated to improve the visible signs of aging caused by advanced glycation end-products (A.G.E.). I didn’t see much of a visible improvement in the signs of aging.
Reduces the appearance of skin creping and thinning. Didn’t do this for me.
Visibly improves the appearance of fine lines, wrinkles, and skin texture. Didn’t see much of a difference here.
Restores water and nutrients to improve the look of skin firmness. I didn’t see much of a difference in firmness.
Comforts dry, aging skin. So not moisturising enough for dry skin.

Price & Availability

$169.00/£160.00 at Blue Mercury

Do You Need It?

No one needs a moisturiser this expensive. But if you’ve got combination skin and a fat wallet, you’ll like this.

Dupes & Alternatives


aqua / water / eau, propylene glycol, dimethicone, hydroxypropyl tetrahydropyrantriol, cyclohexasiloxane, isohexadecane, glycerin, synthetic wax, dimethicone/peg-10/15 crosspolymer, aluminum starch octenylsuccinate, ci 77163 / bismuth oxychloride, phenoxyethanol, magnesium sulfate, ethylhexyl hydroxystearate, salicyloyl phytosphingosine, acrylates copolymer, methylparaben, ethylparaben, disodium edta, vaccinium myrtillus extract / vaccinium myrtillus fruit extract, parfum / fragrance, butylphenyl methylpropional, coumarin