Can Skin Actives Antioxidant Serum With Glutaredoxin And SOD Protect Skin From Enviromental Damage?

by Gio

skin actives antioxidant serum with glutaredoxin and sod

I’m always looking for a good antioxidant serum that helps my skin slow down premature aging without breaking the bank. Chock-full of antioxidants and reasonably priced, Skin Active Antioxidant Serum seems, on paper, to fit the bill. Here’s what it promises:

What Skin Active Says

This ready to use formulation is now our preferred delivery method for our best water soluble antioxidants. Includes our exclusive protein Superoxide Dismutase. Use it to fight free radicals formed by exposure to the sun, pollution, and imperfections in the inner workings of our own mitochondria.

Full Ingredient List

Distilled Water (Aqua), Lactobacillus/Kelp Ferment Filtrate, Sodium PCA, Magnesium Ascorbyl Phosphate (Vitamin C), Niacinamide (Vitamin B3), Carnosine (L-), Carnitine (L-), Tetrahydrocurcuminoids (Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane), Ferulic Acid, Citric Acid, Hyaluronic Acid, Epigallocatechin Gallate (EGCG, Green Tea, Camellia Sinensis Leaf Extract), Hesperidin Methyl Chalcone, Aloe Polysaccharides (Aloe barbadensis Leaf Extract), Lycopene, Glutathione, Glutaredoxin, Superoxide Dismutase (SOD), Catalase, Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben.

Ingredient Analysis


Superoxide Dismutase and Glutaredoxin

According to the company, Superoxide Dismutase and Glutaredoxin are the star ingredients of the serum. Both are antioxidants. Superoxide Dismutase is an enzyme naturally produced by the body to reduce the harmful effects of DNA damage, which can, among other things, cause premature aging. A 2001 study has also found that it can help heal wounds caused from burns in rats.

Glutaredoxin can also reduce oxidative stress damage. However, the only information I could find about it comes from Skin Active, so, while it shouldn’t be entirely dismissed, it should be taken with a grain of salt. At least until further studies tell us more about it. In any case, Glutaredoxin, just like Superdoxide Dismutase, are present only in minuscule concentrations in the serum, so their efficacy is limited anyway. But that’s ok. This serum is chock full of other goods that are very beneficial for the skin.

niacinamide molecular structure


Niacinamide is an ingredient that everyone should incorporate in their skincare routine. It can reduce transpidermal water loss and increase moisture level in the skin (it is even more effective than petroleum jelly), treat acne and hyperpigmentation, soothe rosacea, and can even help reduce fine lines and wrinkles. Impressive, isn’t it?

magnesium ascorbyl phosphate structure

Magnesium Ascorbyl Phosphate

Magnesium Ascorbyl Phosphate is a stable form of Vitamin C. A powerful antioxidant, it can help fight free radicals, thus helping skin stay younger for longer. In addition, it can also increase moisture level in the skin and boost collagen production. Vitamin C also has skin-lightening properties, although it’s unclear whether the serum contains enough of it to reduce dark and sun spots. The only study done on the topic used a 10% concentration of Magnesium Ascorbyl Phosphate. This serum certainly doesn’t contain that much, but it does contain enough to provide antioxidant properties.

Sea kelp Ferment

Lactobacillus/Kelp Ferment Filtrate

After distilled water, Lactobacillus/Kelp Ferment Filtrate is the main ingredient of this serum. What does it do? It forms a protective film on the skin that helps to keep it moisturized. However, it is ambery-yellowish in colour. It may be this, when mixed with all the other ingredients, that gives this serum, a coffee colour. A Truth In Aging reader reported that this makes her fair skin look sallow. She also didn’t like the scent. The serum is fragrance-free, so it may be the lactobacillus/kelp that gives it a not too pleasant scent too.

Final Consideration On The Formula

In addition to Magnesium Ascorbyl Phosphate, Superoxide Dismutase, and Glutaredoxin, the serum contains many other antioxidants, such as Ferulic Acid, Green Tea, and Gluthatione. They all help fight free radicals, which are caused, among other things, by sun damage, pollution, and inflammation, thus helping skin stay younger for longer. In addition, the serum also contains Hyaluronic Acid, a powerful humectant that can attract water from the environment into the skin (it can hold 1000 times its weight in water and is effective in both high and low humidity conditions) and Sodium PCA, which has good water binding properties. Thus, the serum will also help keep your skin hydrated and soft.


Skin Actives Antioxidant Serum with Glutaredoxin and SOD is available at Skin Actives. A 1.0 fluid ounces bottle will set back you back $25.00, which I think is reasonable or this kind of product. A 4.0 fluid ounce bottle is also available at $90.00.

The Bottom Line

Skin Actives Antioxidant Serum With Glutharedoxin and SOD is a well-formulated product chock full of antioxidants, humectants and moisturizing ingredients that will help keep premature aging at bay, and your skin soft and hydrated. However, its colour and smell may bother some people. If you have the chance, I highly recommend you try a sample first.

Have you tried Skin Actives Antioxidant Serum With Glutharedoxin And SOD? And what’s your favourite antioxidant serum?

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Seppo May 6, 2014 - 5:16 am

Seems like this could work for acne. Both niacinamide and vitamin C (as sodium ascorbyl phosphate) have been tested against benzoyl peroxide and topical antioxidants and found to be either more or equally effective. Green tea has been shown to work better than placebo. Also, L-carnatine and green tea have been shown to reduce sebum production. So overall, this looks like a very promising product for acne.

Gio May 6, 2014 - 7:56 pm

Seppo, it would be wonderful if it did. It certainly contains ingredients that could help, thank you for pointing that out. 🙂 Don’t you just love products that can multitask?

Seppo May 10, 2014 - 5:50 am

Yep. I actually recommend my readers to use something like this over benzoyl peroxide and other traditional acne treatments. Or at the very least to make sure their skincare regimen includes some antioxidants.

Gio May 10, 2014 - 8:17 am

Seppo, that’s smart advice! Antioxidants can make a great difference in how our skin ages and behaves. 🙂

Seppo May 11, 2014 - 3:04 am

Indeed. The way I think about is the difference between treating the health of the skin vs. nuking acne away with benzoyl peroxide and tretinoids. Of course those drugs have their uses and can be used on top of antioxidants.

Gio May 16, 2014 - 1:38 pm

I agree. Getting rid of acne is all good, but you need to take care of your skin while doing so or, once you’ve fixed a problem, you’ll have to deal with another one.

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