matrixyl 3000 skincare benefits

Did you know that Matrixyl isn’t just one ingredient?

There’s the original Matrixyl and there’s Matrixyl 3000, a distant cousin developed by the same corporation, Sederma.

Is it better and should you use it? Let’s find out:

What Is Matrixyl 3000?

From the name, you’d be forgiven for thinking Matrixyl 3000 is a new, 3x more powerful version of the original Matrixyl peptide.

That’s probably what Sederma wants you to think…. The truth is different.

Matrixyl and Matrixyl 3000 are both peptides (short chains of amino acids), but that’s where the similarities end.

Matrixyl is the trade name for peptide Palmitoyl Pentapeptide-4.

Matrixyl 3000 is a combination of two peptides, palmitoyl oligopeptide and palmitoyl tetrapeptide-7.

Let’s take a look at both of them separately:

Related: Is Matrixyl A Gentler Alternative To Retinol?


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Palmitoyl Oligopeptide: What Is It And What Does It Do For Skin?

Palmitoyl oligopeptide (Pal-GHK) is made up of three amino acids (GHK peptide or glycine-histidine-lysine) connected to palmitic acid (a fatty acid that helps peptides better penetrate skin).

GHK is a fragment of type I college. Scientists believe that, when you add it back into your skin, it can boost the production of collagen, leading to firmer skin and fewer, smaller wrinkles.

Related: The Truth About Peptides: Do They Really Work?

Palmitoyl Tetrapeptide-7: What Is It And What Does It Do For Skin?

Palmitoyl tetrapeptide-7 (Pal-GQPR, formerly known as palmitoyl tetrapeptide-3) is made up of four amino acids (GQPR peptide or glycine-glutamine-proline-arginine) attached to palmitic acid.

Palmitoyl tetrapeptide-7 is said to work by reducing the production of interleukin-6 (IL-6), a molecule that triggers inflammation.

Inflammation is one of your skin’s biggest enemies. It starts a chain reaction that leads to free radicals, wrinkles, and saggy skin. By reducing inflammation, you can slow down premature aging.

Related: What Type Of Peptide Should You Use?

Matrixyl 3000: How Does It Benefit Skin?

Sederma didn’t put together palmitoyl oligopeptide and palmitoyl tetrapeptide-7 randomly. According to their research, these two peptides have an incredible synergy that makes them work dramatically better together than on their own.

In a small human study with 24 volunteers, Matrixyl 3000 worked much better than the placebo treatment and Matrixy. Here are the results after 2 months of daily use:

  • 14% reduction in skin roughness
  • 15% reduction in wrinkle depth
  • 15% increase in skin tone
  • 18% reduction in wrinkle volume
  • 37% reduction in wrinkle density

These results are promising, but they come from a manufacturer’s study, so take them with a pinch of salt.

Related: Treatment VS Prevention: What Really Works Against Wrinkles?

Is Matrixyl 3000 Safe?

In the short-term, Matrixyl 3000 is safe and doesn’t have any side effects. But, as it’s a new ingredient, we don’t have any data on its long-term safety, yet.

What Are The Best Skincare Products With Matrixyl 3000?

The Bottom Line

Matrixyl 3000 is said to be a powerful peptide that can soothe inflammation, reduce wrinkles, and make skin firmer. But, due the lack of independent research, I wouldn’t go out of my way to try it. I’m sticking to my old and trusted retinol for now.