use retinol and azelaic acid together

Can you use retinol and Azelaic Acid together?

Retinol and Azelaic Acid are two skincare superheroes with the same job description: they help you fight acne AND fade away hyperpigmentation. Yep, the best skincare ingredients are multi-taskers that tackle more than one concern.

If your face is covered in pimples and/or dark spots, should you use retinol or Azelaic acid? Or is it safe to use them both together? Let’s find out what the science says:

What Is Retinol And What Does It Do?

Retinol is a form of Vitamin A available off the counter. It must be converted into Retinoid acid (Tretinoin) into the skin for it to work its anti-aging magic.

Vitamin A in all its forms (including retinol) is the only treatment that’s been proven to work to reduce wrinkles. Here’s what it does:

  1. It accelerates cellular turnover: It speeds up your skin’s natural exfoliating process by prompting skin cells to turn over and die quickly, so that new, healthy ones can take their place. Result? Softer and smoother skin.
  2. It boost collagen: Collagen is the protein that makes skin thicker and firmer. Retinol prevents its breakdown and loss, keeping your skin firmer and younger-looking for longer.
  3. It has antioxidant properties: It fight free radicals, the rascals that cause premature wrinkles and dark spots.
  4. Treats acne: By speeding up cellular turnover, it helps dead skin cells fall off your skin. This matters because, when dead cells accumulate onto your skin too much, they end up falling into your pores and clogging them up. Next thing you know, you’re breaking out like crazy. Because of its exfoliating action, retinol helps get rid of whiteheads and clogged pores.

Or, said more simply, retinol:

Related: The Complete Guide To Retinol: What It Is, What It Does, And How To Use It


Don’t know which skincare products you can mix and match together and which ones deactivate each other? Download your FREE “How To Layer Actives Like A Pro” cheat sheet to get the most out of your skincare products:


What Is Azelaic Acid And What Does It Do?

Did you know Azelaic acid is made by the healthy bacteria that live on your skin? How cool is that? This multitasker helps treat acne, hyperpigmentation, and even rosacea. Here are just a few of its benefits:

Related: The Complete Guide To Azelaic Acid In Skincare

l'oreal Revitalift Laser Pure Retinol Night Serum review

Retinol VS Azelaic Acid: What’s The Difference?

Both retinol and azelaic acid can treat acne and dark spots, but there are three key differences between the two:

  • Mode Of Action: Azelaic acid exfoliates skin and pores, getting rid of dead skin cells. It just… doesn’t do it very well. It’s weaker than other acids, like Glycolic and Salicylic. Retinol speeds up cellular turnover, i.e. the skin’s natural exfoliating process. It doesn’t remove dead cells, but encourages skin to shed them faster. It may be a small difference, but it matters.
  • Irritation: Retinol is very irritating. When you first start using it, it can cause dryness, irritation, redness, and peeling. Azelaic acid, on the other hand, is gentler and, usually, well tolerated even by people with sensitive skin.
  • Anti-Aging: Retinol is an anti-aging superstar that can (in the long run – nothing works overnight when it comes to anti-aging!) reduce wrinkles and prevent new ones from forming. Azelaic Acid will make your skin look younger by tackling acne and dark spots, but it’s not as powerful when it comes to fighting wrinkles.

Who Should Use Retinol?

Retinol is the best wrinkle fighter available OTC. If you want to tackle wrinkles as well as acne and/or hyperpigmentation (or all three of them) AND your skin isn’t sensitive, retinol is the way to go. There’s a reason why it’s so hyped up. It just works.

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Who Should Use Azelaic Acid?

If you’re dealing with acne or dark spots AND you have sensitive skin that can’t tolerate retinol, then Azelaic acid is the best option for you. It does the job without irritating your skin.

I know, I know, it’s not as good to treat wrinkles BUT retinol has side effects. You’re not going to look younger if your skin is all red, inflamed, and peeling from the retinol. Plus, retinol can dry out your skin, making the wrinkles you already have look worse. Do your sensitive skin a favour, and stick to Azelaic Acid and a good moisturiser.

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Can You Use Retinol And Azelaic Acid Together?

Still undecided? If your skin isn’t sensitive and can take the extra load, you can use retinol and Azelaic acid together.

This works especially well for hyperpigmentation, like dark spots, melasma, and post-inflammatory hyperpigmentation (the dark spots left behind by pimples).

Azelaic acid inhibits the activity of the tyrosinase enzyme, which is essential for the production of melanin (the pigment that gives skin its natural colour). Stop it from overacting and you stop the overproduction of excessive pigment.

Retinol, on this other hand, fades away dark spots by speeding up cellular turnover, i.e. the skin’s natural exfoliating process. In other words, it helps skin renew itself faster so that the older, darker cells on its surface give way to the newer and brighter cells underneath.

Use retinol and Azelaic acid together and you tackle dark spots on two fronts. Studies show retinol and azelaic acid are both effective when used alone, but work even better when paired together!

There’s also some research that shows that azelaic acid boosts the anti-acne effects of retinol. If you have severe acne, pairing these two actives together can help you heal faster.

WARNING! As always, you need to take these results into context. If you have severe acne and sensitive skin, the combination of retinol + Azelaic Acid will help you heal faster. It may cause some irritation, but the trade off is worth it. BUT, if your acne isn’t as severe, then don’t be tempted to go overboard. Irritating your skin to get faster results is NOT a good idea and will only set your recovery journey back.

Related: All The Stages Of Acne: Causes And Treatments

paula's choice azelaic acid booster vs the ordinary azelaic acid suspension

How To Use Retinol And Azelaic Acid Together

The best way to use retinol and Azelaic acid together is to get a product that has both, like VI Derm Retinol Age-Defying Moisturizer ($104.00).

If that’s out of your budget, the next best option is to layer two products, one with retinol, and one with Azelaic acid. For best results, apply the one with the thinnest consistency first. If both have the same consistency, then the order doesn’t matter.

Still, when you’re starting out, I recommend you introduce them one at a time. Use retinol for one month and then introduce azelaic acid (or vice versa). In case of an adverse reaction, this’ll help you determine who the culprit is. Plus, it gives your skin time to get used to these ingredients.

If using them together is too much for you, you can always alternate them at night. Never use retinol in the morning. It makes your skin more prone to sun damage!

Related: How To Layer Skincare Ingredients Like A Pro

The Bottom Line

You can totally use retinol and Azelaic acid together to tackle acne and hyperpigmentation – IF your skin isn’t sensitive and can take the extra load. If it gets irritated easily, then opt for Azelaic acid. It’s the gentlest of the two.