Niod Copper Amino Isolate Serum 2 review

You don’t know what you’ve got till it’s gone.

That’s how I felt about Niod Copper Amino Isolate Serum. The first time I tried it, it wasn’t love at first sight. It just didn’t seem to do anything!

But when I ran out, oh my, did I see a difference! I couldn’t put my finger on it but somehow, my skin just didn’t look as good anymore. It took longer to heal. It was just behaving differently (and not in a good way!).

What was going on?

Copper is a shy skincare hero. It doesn’t make wrinkles disappear or plump up your skin so much you wonder where your fine lines have gone to.

Instead, it targets the signs of aging INDIRECTLY: it keeps the skin in a constant state of repair, making sure the processes that produce collagen, reduce inflammation, and heal skin are working well.

In plain English, if your skin’s in good condition (like mine is), it just maintains the status quo.

If it’s in a bad shape, you’ll notice your breakouts heal faster, your pores look smaller, and flakiness become a thing of the past. If you have sensitive skin, it may also make it more resistant to redness and irritations!

If Niod Copper Amino Isolate Serum could do all this before, can you imagine how much better it works now that they’ve upgraded the formula?

What’s In Niod Copper Amino Isolate Serum 2:1 (CAIS 2)?


Let’s set the record straight from the beginning: Niod Copper Amino Isolate Serum 2:1 isn’t the second version of the old CAIS 1%. It’s a new formula with a different 2% strength of copper peptides.

The 2:1 name in the serum comes from the 2-to-1 ratio of copper peptides GHK to GHK-Cu. I’ll try to make this as simple as possible, but bear with me.

Like the old formula, the new ones comes with a serum and an activator you have to mix together. The Activator contains 2% pure GHK (Tripeptide-1) while the Serum has Copper Gluconate, a different form of copper.

When you mix them together, 1% of GHK attaches to the Copper Gluconate to form 1% GHK-Cu (or Copper-Tripeptide-1). The other 1% remains in free form.

So, what does that mean for your skin?

A few things. Studies on Copper-Tripeptide-1, for example, show that it:

Put simply, it makes sure your skin is repairing itself properly and making enough collagen to stay firm and young.

P.S. When you’re young, your skin makes enough copper peptides on its own so you DON’T need this. You know it’s time to add it into your skincare routine once you’re reached the big 3-0.

Related: Are Copper Peptides Better Than Retinoids For Anti-Aging?

Struggling to put together a skincare routine that fights wrinkles and gives your skin a youthful glow? Download your FREE “Best Anti-Aging Skincare Routine” to get started (it features product recommendations + right application order):


If you’re worried that a higher concentration of copper peptides translates into a thicker, sticky texture, don’t. Its consistency is every bit as watery and lightweight as its predecessor. It absorbs just as fast. Phew!!


The serum itself is fragrance-free. But the ingredients don’t smell the best. Still, it fades away fast, so it doesn’t really bother me.

How To Use It

The first time you use it, pour the content of the Activator into the Serum, shake 30 seconds and you’re good to go. By the way, how cool is the blue colour?

I use CAIS 2 every morning and night right after cleansing. Then, I wait a few more seconds before going in with a serum or moisturiser.

Performance & Personal Opinion

I’ve already mentioned I’ve seen a bigger difference with the first version of this serum AFTER I’ve stopped using it.

Now, they’ve upped the dose, could I see a difference straight away with Niod Copper Amino Isolate Serum 2:1?

Not from the start. Being a skincare geek means I’ve figured out a routine that keeps my skin happy. My young age that I don’t have to deal with deep wrinkles or dark spots just yet. My skin looks good.

For me, CAIS 2 does more of a maintenance job so its effects aren’t visible straight away. But I did notice a small improvement in my skin’s texture after a month of daily use.

If you’re skin is in a bad shape, you may see some results, like healing pimples or smoother texture, faster. You may also notice your skin tolerates acids or other powerful actives better.

niod copper amino isolate serum 2 1

Who Is This For?

If you’re past 30 and you’ve already got all your skincare basics in place, this would definitely make a nice addition to your skincare routine. Just be patient and give it time to work its magic.

Who Is This NOT For?

If you’re young and your skin is still in good condition, this won’t do much for you.


A dark bottle with a dropper applicator. It’s practical and sleek.

niod copper amino isolate serum 2 1 review

Does Niod Copper Amino Isolate Serum 2:1 Live Up To Its Claims?

As a highly-focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all signs of skin aging indirectly. True.
The high 2% concentration of GHK and GHK-Cu in CAIS2 targets signs of skin aging, including visible textural damage, uneven tone, visibly enlarged pores and a general lack of healthy radiance normally present in younger skin. In short, the skin will look healthier with continued visible improvements with continued use. True.

Price & Availability

£38.00 (15ml); £60.00 (30ml) at Cult Beauty and Feel Unique

Do You Need It?

It’s not an absolute must-have. But, if you’re past 30 and have some extra money to burn, this can help your skin stay in top shape.

Dupes & Alternatives


Aqua (Water), Glycerin, Tripeptide-29, Tripeptide-1, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

Copper Concentrate

Aqua (Water), Copper Gluconate, Isoceteth-20, Phenoxyethanol, Chlorphenesin.