The Truth About Niod Copper Amino Isolate Serum: Does It Live Up To The Hype?

by Gio

Have you joined the copper rush, yet?

Retinol and vitamin C are awesome… when they don’t irritate your skin. (Nothing’s perfect, eh?)

I can totally see why some ladies are cheating on them with something gentler. Like copper peptides. They’re the new magic bullet that will solve all your skin’s woes. Or so they say.

You know me. I have to put my science cap on and try them for myself. The serum on trial? Niod Copper Amino Isolate Serum (CAIS) 1%. 

Not that I’ve ever had a choice. You guys have bombarded me with requests for this review. You’re really, really, really curious about it. So, does it live up to the hype?

Copper Tripeptide-1

This is a peptide found in human plasma that activates a lot of functions in the body, including wound healing, collagen production and anti-inflammatory responses.

But, like all good things, your body starts to produce less as you get older. It all starts in your early ’20s and, by the time you’re 60, it has dropped by a whopping 60%.

So, you need to add it back. Problem is, most skincare products out there only feature a smidge of it. But here, it is the star of the show. There’s a whole 1% of it. I know that sounds like nothing but, when it comes to copper tripeptide-1, it’s a lot to get the job done.

So, what does it do in skincare? Studies have shown that:

Can it get rid of wrinkles? In theory, it’s possible. In practice, the jury’s still out there. To be honest, we don’t even know if peptides can penetrate the skin.

They’re so big, they shouldn’t. But, some scientists think they still work when left on the surface of the skin. According to this theory, they send a signal to the cell telling it what to do (like, “make more collagen, you lazy thing! Can’t you see that everything is falling apart here?).

Either way, as Niod itself says on its website, CAIS ain’t for wrinkles. Its job is to activate all these different body functions (like wound healing and collagen production) to keep your skin in a constant state of repair.

Basically, it treats the signs of premature aging indirectly. Interesting approach, isn’t it?

Copper Lysinate Prolinate

This peptide is here to enhance penetration and boost collagen production even more.

I wish I could write a poem about it, but I couldn’t find much about it. There is some research that copper lysinate, for example, can increase the production of collagen. Apparently, it does this better than vitamin C!

I do believe this peptide does something good for the skin, but exactly how well it works is to be determined. I’ll keep an eye out on future studies and let you know what science finds out.

Related: Are copper peptides better than retinoids?

Sodium Hyaluronate Crosspolymer

I’ll never tire of singing the praises of sodium hyaluronate. A close relative of hyaluronic acid, it can attract and bind to the skin up to 1000 times its weight in water!

It basically keeps skin hydrated. And when skin is hydrated, it is softer to the touch, all plumped up (who can see those pesky wrinkles now) and glows beautifully!

How Do You Use Niod Copper Amino Isolate Serum?

CAIS comes in two bottles. One contains the copper peptide and the other its activator. Pour the activator into the copper peptide bottle and shake well for 30 seconds.

Why the fuss? If you mix it yourself, you know the serum’s as fresh as it can be. You only have 6 months to use it so you don’t want to get a bottle that’s already gone bad.

Once ready, use it twice a day.

Let’s Put It To The Test

Niod CAIS is one of the most lightweight serums I’ve ever tried. It sinks into my skin immediately.

It’s not very hydrating. There may be plenty of sodium hyaluronate in it but if I don’t apply moisturizer straight afterwards, my skin feels dry. That usually doesn’t happen with other SH serums.

Oh, well, this isn’t a hydrating serum anyway. It’s for skin health / indirect anti-aging.

So, how does it do that? Well, I didn’t get a big improvement within 5 days as Niod promises. And I’m not totally convinced copper peptides are better than vitamin C.

When I use vitamin C, I can see the results (some of them, anyway!) straight away. I’m talking about that pretty glow it gives to the skin. I didn’t get that with CAIS. But I guess that’s because of the way CAIS works.

I’m in my mid 30s, but I’ve been avoiding the sun like the plague for more than a decade now, wear my sunscreen religiously and use all the right anti-aging superstars.

So, even though CAIS keeps my skin in a constant state of repair, I guess my skin doesn’t give it all that much work to do. My skin is already soft and even-toned so CAIS is helping my skin maintain the status quo, which is totally cool with me.

Although, I do think that, after one month of use, my skin has become a little bit firmer than it used to be.

Should You Use Niod Copper Amino Isolate Serum?

It depends.

If you’re still young and your skin is doing everything it’s supposed to be doing, then no, you don’t need to splurge on CAIS. Use sunscreen every day, get a good antioxidant serum and eat more veggies than sugar and you’ll be able to prevent a lot of the damage in the first place.

If you’re older and could use the extra help, then you may consider adding CAIS to your skincare routine. But, don’t give up your retinol or vitamin C for it.

Price & Availability: £38.00 at Selfridges and $48.00 at Look Fantastic


Copper Concentrate Ingredients:Aqua (Water), Copper Tripeptide-1, Sodium Hyaluronate Crosspolymer, Pentylene Glycol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

Activator IngredientsAqua (Water), Glycerin, Dimethyl Isosorbide, Decapeptide-22, Oligopeptide-78, Palmitoyl Decapeptide-21, Zinc Palmitoyl Nonapeptide-14, Myristoyl Nonapeptide-3, Copper Lysinate/Prolinate, Methylglucoside Phosphate, Hydrolyzed Wheat Protein, Arginine, Pentylene Glycol, Xanthan Gum, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethoxydiglycol, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Phenoxyethanol, Chlorphenesin

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Sherry G March 15, 2017 - 4:18 pm

It sounds intriguing, and at age 57 I probably could see some benefit. However, my budget can’t handle any more skin care add ins, lol. I have found a Vitamin C that works well for me, and is affordable. It’s Skin Deva’s 20% Vitamin C+E+Ferulic Acid. It’s the same ingredients as Timeless, but for some reason works better with my skin. I had no glow with Timeless, but do get it with Skin Deva. Skin care is certainly fascinating! Thanks for the review of the copper serum.

Gio March 18, 2017 - 7:14 pm

Sherry, my pleasure. So glad to hear you’ve found an affordable vitamin C serum that works well for you. As for NIOD CAIS, the bottle is quite small so if you use it twice a day, you’ll finish it before the six months are up. Just something to consider if you want to add it to your skincare routine in the future.

Minn March 16, 2017 - 11:39 pm

With those healing and skin repairing properties, it sounds like it would be good for acne, don’t you think? Also are you supposed to wait after applying CAIS or is it ok to apply other products directly after it?

Gio March 19, 2017 - 8:32 pm

Minn, I know some people who say copper peptides has helped them heal their acne scars, but there isn’t much scientific research on this at the moment. I do think it’s best to wait until it has absorbed. And this absorbs super quickly so you don’t won’t have to wait more than a couple of seconds.

Minn March 20, 2017 - 4:08 pm

Thank you, good to know!

Gio March 20, 2017 - 4:52 pm

You’re welcome!

Cristina April 21, 2017 - 2:55 pm

This is the only anti aging serum i can use on my acne prone skin (i am 46). I was really worried when i found out it is not oil free because anything not oil free usually breaks me out, but this one did not . Not immediate results; you see the results when you stop using it . You realized that, yes , it does work ;))

Gio April 21, 2017 - 7:43 pm

Cristina, I agree. I didn’t use it for a couple of weeks and could definitely see a difference.

Cristina April 21, 2017 - 8:00 pm

🙂 Happy i am not the only one who experienced that .

Sheila Davis May 20, 2017 - 8:10 am

I try ing to find the best eye cream or oil for my sensitive Eyes ,to reduce puffiness and wrinkles,

Gio May 21, 2017 - 9:39 am

Sheila, as long as it’s gentle and fragrance-free, your face moisturizer will do the job. Eye creams are just facial moisturizers packaged in smaller jars, anyway, so don’t waste your money on them.

majorie August 12, 2017 - 12:50 pm

Hi! i just found your blog, i found it so interesting. I’m 30 years old and i was blessed with a very sensitive skin. I had very bad skin reaction to Retinol and Vit C ( i think i tested all the brand on the market) I decided to gave up Retinol and Vit C a few months ago, my skin is getting so much better right now. I was considering give this copper peptide a try, i would like to know your opinion about this, would you consider this serum good and gentle for sensitive skin?

Gio August 19, 2017 - 9:22 pm

Majorie, so sorry vitamin C and retinol aren’t working for you. Sadly, the best ingredients are often the harshest. 🙂

Yes, copper peptides are usually safe for sensitive skin.

Chloe Grice September 23, 2017 - 6:57 pm

I personally think vitamin c n sunscreen is better IF you are regularly outdoors. In my experience copper peptide works really well in the winter when its not worth going outdoors.

Gio September 29, 2017 - 12:25 pm

Chloe, thanks for sharing your experience. I personally use both. 🙂

Christalla October 3, 2017 - 9:22 am

Hi I’m about to start derma rolling for the first time and was wondering if it would be ok to use the niod copper peptide with it?

Gio October 6, 2017 - 9:23 pm

Christalla, yes you can use them together.

PAOLA PAVOURIS January 26, 2018 - 11:55 pm

Can you use Retinols, Vitamin C and Retin A in conjuction with this product?

Gio February 2, 2018 - 3:36 pm

Paola, yes you can. But I wouldn’t use retinol with retin A. They’re both forms of vitamin A, so just pick one.

fyNl February 7, 2018 - 9:50 am

Finally got around to using this after taking a brief break from Vitamin C, Ferrulic & Phytic Acid. After 23 nights, I’m just not impressed. It just does not appear to do anything. Maybe a little clearer skin on the chin, but that’s it.
(I am 39 with somewhat sensitive and dehydrated skin that is starting to see laxity)

Gio February 10, 2018 - 5:43 pm

Fynl, I had a similar experience at the beginning. It’s when I stopped using it that I noticed a bigger difference. I guess that’s because the serum is supposed to keep your skin in good condition so as long as your skin’s happy, it may not look like it’s doing much.

Copper peptides are proven to boost collagen but it’s also important to be realistic. It can make skin a little firmer but it can’t stop sagging completely. No topical can.

DrM February 27, 2018 - 8:27 pm

Hi Gio. Thanks for the interesting article. As a doctor I found this really informative and well explained. I’ve just purchased my first bottle and am keen to get started. I dont have a specific issue I want this to miraculously cure, but I do want something that will help me maintain my skin health (along with daily SPF obvs!)
I can see you feel that you only appreciated what this stuff was doing for you when you stopped using it. I was wondering – was this a rebound reaction? Ie did your skin go back to normal and after how long? I’m querying whether your skin becomes a little “addicted” to it…..
Many thanks DrM

Gio March 2, 2018 - 5:30 pm

DRM, if you just want something that maintains your skin’s health, this is perfect.

I’ve been using it on and off (currently using the 2.0 version) and I have to say my skin always look a little bit better when I’m using it. I find that it helps my skin function as it should on its own so when you use it, it’s like you’re taking your great skin for granted.

My skincare routine always includes some form of retinol and glycolic acid so when I stopped using it, the difference wasn’t too stark. It was just that with this, it was like I had to do less of an effort if that makes sense?

flavia March 5, 2018 - 2:39 am

can you tell me if you apply your retinol or your vit c after cais

Gio March 16, 2018 - 10:28 am

Flavia, yes I do. I just wait a few minutes between each layer.

Tatiana July 11, 2019 - 3:17 pm

Hi Gio, thanks to you I have tried products that works great on my skin. I really appreciate you sharing your knowledge in a honest way.
Can I use CAIS morning and evening every day without a break ? Is it ok to use before votam C, retinol 1% or AHA?

Gio August 8, 2019 - 4:25 pm

Tatiana, I wouldn’t use it every day twice a day because too much copper is bad for skin. Everything in moderation! But you can definitely use it before retinol.

KJ November 13, 2019 - 8:04 am

Hi! Can I incorporate this cais2 and mmhc2 in my daily am skincare routine if Im already using skinceuticals c e ferulic? Which should I apply first after cleansing, cais2 or c e Ferulic?

Gio December 15, 2019 - 11:17 am

KJ, you can use mmhc2 with anything, but use cais2 at night instead.


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