Know Your Ingredients: Palmitoyl Pentapeptide-3

by Gio


What it is
Palmitoyl Pentapeptide-3, also known as Matrixyl and Palmitoyl Pentapeptide-4, is a pentapeptide created by Sederma SA and Proctor & Gamble.

What it does
Palmitoyl Pentapeptide-3 stimulates the production of collagen, elastin, and glycosaminoglycans. It improves the appearance of fine lines and wrinkles and the skin’s moisturization levels, and, overtime, its firmness.

Side effects
Palmitoyl Pentapeptide-3 is generally considered to be safe. However, according to Sederma, this ingredient should be used in concentrations ranging from 3% to 5% to work properly, and very few, if any, products on the market contain the recommended amount.

(Sources: International Journal of Cosmetic Science and Cosmeceutical Peptides, 2007)



Marianthi May 13, 2012 - 9:28 am

Very useful as all your posts, thanks!

beautifulwithbrains May 13, 2012 - 7:32 pm

Marianthi, you’re welcome.

Janessa May 15, 2012 - 5:03 am

Wow what a powerful ingredient. It seems like all the big companies have a unique product they’ve created like L’Oreal and mexoryl which makes sense because they have the money to invest! I really admire you, Giorgia! You’re consistently posting and never lacking in quality!

beautifulwithbrains May 15, 2012 - 6:15 am

Janessa, that’s so right. Luckily these companies own lots of brands so they can put these ingredients also in drugstore products that anyone can afford.

Aww thank you! That means a lot to me! 😳

june demichele March 7, 2013 - 12:50 pm

Is palmitoyl peptide 3 the same as palmitoyl pentapeptide3??? The first ingredient is in a cream I use called Posh Pure Collagen anti aging complex. It alsohas palmitoyl peptide 7. I would appreciate any info you have on these two peptides.

beautifulwithbrains March 8, 2013 - 7:48 pm

June, yep, they are. Palmitoyl pentapeptide 3 is also called Matrixy and it’s a fatty acid mixed with amino acids. It is said to stimulate collagen synthesis and skin repair, but the only studies proving its effectiveness are done by the company that makes it. Besides, the company claims it is most effective at 3% to 5% concentrations and very few creams, if any, contain that much.

Palmitoyl peptide 7 is said to work pretty much the same, but again the research on it has been done by the company that makes it. This doesn’t mean they don’t work. The data is promising indeed, and I think it’s good to try and incorporate peptides into your skincare routine, but until these findings will be confirmed by independent studies, I would also keep using ingredients proven to work like retinoids and vitamin c.

june demichele March 8, 2013 - 7:55 pm

Thank you for your response. Are we straight on palmitoyl PEPTIDE 3 versus Palmiytol PENTAPEPTIDE 3?? I wanted to know if there is a differnece between PEPTIDE 3 and Palmityol PENTAPEPTIDE 3. My product , Posh, has the PEPTIDE 3 and not PENTAPEPTIDE 3……please straighten me out!

beautifulwithbrains March 8, 2013 - 8:07 pm

June, I always assumed they were pretty much the same because I always heard them both referred as matrixyl. But new peptides are popping out quite often lately, so there may be a difference between the two.

I am 100% sure that Palmitoyl Pentapeptide-3, which has later been renamed palmitoyl pentapeptide-4, is matrixyl. I will have to do some more digging on Peptide 3 and then let you know.

EDIT: Peptide 3 seems to be called motrixyl. It’s very similar to matrixyl, which I think is where the confusion originated. I haven’t been able to find any other information atm, but I’ll keep looking.

june demichele March 9, 2013 - 1:00 pm

I used the POSH on my husband’s under eye last night and it seem to immediatly puff up the area. He thought it was TOO puffed up. I will look again today to see if I agree with him, but if you know anything about the product POSH Pure Collagen Anti Aging Complex is there a product they make jsut for the eye area with peptides that may not be as strong for that delicate area? Do you know and recommed one? I know their claim on collagen building is bogus because I have done research and learned that collagen CANNOT be absorbed into the skin. Do you agree with that finding?
Thanks for your comments.

beautifulwithbrains March 14, 2013 - 10:59 pm

June, sorry for my late reply. I’m sorry the Posh product didn’t work for your husband. Have you tried Olay Regenerist Eye Lifting Serum? It contains Palmitoyl Pentapeptide-4, a mix of antioxidants and niacinamide, which is one of my fave ingredients as it can help prevent water loss, improve skin’s elasticiity and even fade discolorations.

And yes, collagen molecules are too big to penetrate the skin. They simply stay on the surface and moisturize it, but nothing more.

june demichele March 9, 2013 - 3:45 pm

I, too, can’t find any informatiom om motrixyl. Are we to assume that it is safe as matrixyl?

beautifulwithbrains March 11, 2013 - 10:32 pm

June, yes. They wouldn’t have been able to use it if they had known it was dangerous. It’s just frustrating not to be able to find more information about it to see how effective it really is.

jan September 14, 2015 - 9:29 pm

Hi im concerned that Palmitoyl Pentapeptide-3 may be a derivative of Palm Oil. Deforestation is occurring on a massive scale so that farmers can plant palm oil and get a high price – this is leading to the habitat of Orang Utans’ being desimated and the Orang Utan population reducing daily because they wander into villages for food and are killed or beaten.

I really hope that this wonder cream doesnt contain palm oil as if it does i certainly wont be buying it!

Gio September 15, 2015 - 11:03 am

Jan, I think this may be a derivative, unfortunately. I’ll do some digging, and see what I can find out.


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