Isn’t it annoying when it’s the gold standard for something that gets a bad rep?
Case in point: hydroquinone. It’s by far the best treatment for any type of dark spots. Slather it on them and it’s guaranteed to lighten them up.
But, some countries (yes, South Africa and France, I’m looking at you) have banned it after rumours it causes cancer and other nasty stuff started doing the rounds.
Is this true? Are politicians really trying to protect us from serious harm or are they misunderstanding the science and being too hasty with their bans?
Hint: scientists say that a hydroquinone ban is an “unnecessarily extreme“.
Here’s the scoop on hydroquinone and why it’s not really that dangerous (but you should still use it with caution):
How does hydroquinone work?
Hydroquinone is very effective at treating sun spots, melasma, freckles, postinflammatory hyperpigmentation and pretty much any other type of discolouration.
It works by inhibiting the activity of tyrosinase (the enzyme that controls the synthesis of melanin) and by increasing the cytotoxicity of melanocytes (it kills the cells that produce melanin).
In the US, hydroquinone can be used in concentrations up to 2% in OTC products and 4% in prescription products. Either way, make sure it’s housed in an air-tight, opaque tube. Hydroquinone oxidises (i.e. becomes ineffective) when exposed to light and air. You’ll know when this happen. Hydroquinone turns brown to warn you.
Does hydroquinone cause cancer?
According to the rumours, it does. The “proof”? Hydropquinone can cause cancer in rats.
Never mind that we’re not rays and that those poor animals were injected or fed high amounts of hydroquinone. *sighs* Anyone who understand how to read a scientific study will tell you that these studies simply don’t apply to humans. Especially not when humans use a tiny amount on a small area of skin.
Plus, as Dr Levitt points out in his The safety of hydroquinone: A dermatologist’s response to the 2006 Federal Register , hydroquinone increases benign liver tumours in mice but it DECREASES cancerous liver tumours. This suggests that hydroquinone may actually have a protective effect!
So, nope, there’s NO proof that hydroquinone causes cancer in humans.
Does hydroquinone cause ochronosis?
Ochronosis. It’s a bluish black discoloration of the skin caused by a build-up of tyrosine or phenylalanine. It’s more common in people with dark skin but everyone can get it.
But it’s rare. According to Dr Levitt, “a literature review of exogenous ochronosis and clinical studies employing hydroquinone (involving over 10,000 exposures under careful clinical supervision) reveal an incidence of exogenous ochronosis in the United States of 22 cases in more than 50 years”.
Its rarity makes it difficult to figure out why it happens. It’s obvious hydroquinone alone can’t be the cause or everyone who uses it would get it.
The most popular theories believe you get ochronisis when you use hydroquinone with resorcinol (another ingredient that treats hyperpigmentation) or without sunscreen. If you don’t use one, the theory goes, your skin tends to produce more melanin to protect itself from the sun, compromising the efficacy of hydroquinone.
Bottom line: if you use hydroquinone with sunscreen and without resorcinol, you should be fine.
Can hydroquinone cause irritations and allergies?
It’s not over. Hydroquinone is accused of causing irritations and allergies, too.
If you have sensitive skin, hydroquinone is as guilty as charged. Like all the most powerful ingredients, its effectiveness comes at a cost: redness and irritations.
To minimize irritations, derms recommend you use hydroquinone in a 4 months cycle. This means using hydroquinone for 4 months, then switching to another skin-lighter (for example, azelaic acid) for 4 more months, then back to hydroquinone for 4 months. You get the drill.
What Are The Best Products With Hydroquinone?
- Alpha Skincare Dual Action Skin Lightener ($10.99)
- Paula’s Choice Resist Triple-Action Dark Spot Eraser 7% AHA Lotion ($27.00)
The bottom line
Hydroquinone is the most effective way to treat hyperpigmentation. It won’t give you cancer, rarely ochronosis and sometimes, irritations (but there are tricks to minimise this). Just remember to put your sunscreen on!
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Do you use hydroquinone to deal with your dark spots? Share your thoughts in the comments below.